China Health Trip

Doctor Profile

Dr. Guoying Huang

Pediatric Cardiology

Professor · Chief Physician · Director · MD

Dr. Huang is Director of Shanghai Key Laboratory of Birth Defect Prevention and Control, Director of National Newborn Congenital Heart Disease Screening Program Management Office, President of Pediatric Physicians Branch of Chinese Medical Doctor Association, Vice Chairman of Rare Diseases Branch of Chinese Medical Association, Vice Chairman of Pediatrics Branch/Head of Cardiovascular Group of Chinese Medical Association, Head of Shanghai Model Worker Innovation Studio for Pediatric Cardiovascular Specialty, Head of Shanghai Local High-Level University Innovation Team for Pediatric Rare Diseases, and Young and Middle-aged Expert with Outstanding Contributions of the Ministry of Health.

Pediatric Cardiology

Non-invasive CHD

Integrated Care

Pediatric Screening

30+ yrs

Experience

500+

Papers

23 Authorized Patents

Expertise

Specializes in non-invasive diagnosis of congenital heart disease, with expertise in multimodal imaging and molecular analysis for precision intervention. Renowned for Kawasaki disease management, particularly coronary lesion prevention. Skilled in designing integrated care pathways that bridge early detection to targeted treatment, with a focus on improving pediatric cardiovascular outcomes.

Professional Background

Dr. Huang has dedicated over 40 years to pediatric cardiovascular medicine, emerging as a leading figure in congenital heart disease (CHD) and Kawasaki disease research. He pioneered China’s national neonatal CHD screening program, establishing standardized protocols that revolutionized early diagnosis. As a key driver in integrating birth defect prevention and rare disease management, he led the development of large-scale pediatric screening systems, advancing the field through clinical innovation and academic leadership.

Video Case Studies

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Awards & Honors

Advanced Individual of the National Health System
First Prize of Shanghai Science and Technology Progress Award
First Prize of Shanghai Teaching Achievement Award
Baosteel Excellent Teacher Award
Tan Jiazhen Clinical Medicine Award
Shanghai Mayor’s Quality Award
Outstanding Young and Middle-aged Expert with Significant Contributions, Ministry of Health of China
National Outstanding Healthcare Worker
Outstanding Hospital Director in China
China Pediatrician Award Recipient
Author of over 500 peer-reviewed articles in journals such as The Lancet, Annals of Internal Medicine, and Nature Communications
Author or co-author of 32 textbooks and monographs, holder of 23 patents
Mentor of more than 80 graduate students

Recent Key Publications:

Zhao JY, Yang XY, Gong XH, Gu ZY, Duan WY, Wang J, Ye ZZ, Shen HB, Shi KH, Hou J, Qiao B, Chen YJ, Huang GY, Jin L, Wang HY. Functional Variant in Methionine Synthase Reductase Intron-1 Significantly Increases the Risk of Congenital Heart Disease in the Han Chinese Population. Circulation. 2011 Nov 1;124(18):1997–2005. doi: 10.1161/CIRCULATIONAHA.111.050245. PMID: 21947201.（IF=39.918）
Chen HY, Zhang Y, Wang DM, Chen XT, Li MR, Huang XY, Jiang Y, Dou YL, Wang Y, Ma XJ, Sheng W, Jia B, Yan WL, Huang GY. Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease: Nested Case-Control and Mendelian Randomization Studies. Ann Intern Med. 2022 Oct;175(10):1423–1431. doi: 10.7326/M21-4551. PMID: 35994746.（IF=25.391）
Zhao JY, Yang XY, Shi KH, Sun SN, Hou J, Ye ZZ, Wang J, Duan WY, Qiao B, Chen YJ, Shen HB,Huang GY, Jin L, Wang HY. A Functional Variant in the Cystathionine β-Synthase Gene Promoter Significantly Reduces Congenital Heart Disease Susceptibility in a Han Chinese Population. Cell Res. 2012 Feb;23(2):242–253. doi: 10.1038/cr.2012.135. PMID: 22986502; PMCID: PMC3567826.（IF=25.617）
Ji H, Liang H, Yu Y, Wang ZL, Yuan W, Qian X, Mikkelsen EM, Laursen ASD, Fang GH, Huang GY, Miao MH, Li J. Association of Maternal History of Spontaneous Abortion and Stillbirth With Risk of Congenital Heart Disease in Offspring of Women With vs Without Type 2 Diabetes. JAMA Netw Open. 2021 Nov 1;4(11):e2133805. doi: 10.1001/jamanetworkopen.2021.33805. PMID: 34757411; PMCID: PMC8581719.（IF=13.800）
Wang HJ, Xiao FF, Huang GY, Zhou WH. Genetic Architecture in Neonatal Intensive Care Unit Patients with Congenital Heart Defects: A Retrospective Study from the China Neonatal Genomes Project. J Med Genet. 2023 Sep;60(9):897–904. doi: 10.1136/jmg-2022-108925. PMID: 35595280.（IF=11.360）
Ewart JL, Cohen MF, Meyer RA, Huang GY, Wessels A, Gourdie RG, Chin AJ, Park SMJ, Lazatin BO, Villabon S, Lo CW. Heart and Neural Tube Defects in Transgenic Mice Overexpressing the Cx43 Gap Junction Gene. Development. 1997 Apr;124(7):1281–1292. PMID: 9118799.（IF=6.688）
Xu X, Li W, Huang GY, Meyer R, Chen T, Luo Y, Thomas MP, Radice GL, Lo CW. Modulation of Mouse Neural Crest Cell Motility by N-Cadherin and Connexin 43 Gap Junctions. J Cell Biol. 2001 Jun 25;154(1):217–230. doi: 10.1083/jcb.200103013. PMID: 11448988; PMCID: PMC2196865.（IF=10.539）
Huang GY, Cooper ES, Waldo K, Kirby ML, Gilula NB, Lo CW. Gap Junction–Mediated Cell–Cell Communication Modulates Mouse Neural Crest Migration. J Cell Biol. 1998 Dec 14;143(6):1725–1734. doi: 10.1083/jcb.143.6.1725. PMID: 9852163; PMCID: PMC2132985.（IF=10.539）
Zhao QM, Ma XJ, Ge XL, Liu F, Yan WL, Wu L, Ye M, Liang XC, Zhang J, Gao Y, Jia B, Huang GY. Pulse Oximetry with Clinical Assessment to Screen for Congenital Heart Disease in Neonates in China: A Prospective Study. Lancet. 2014 Aug 30;384(9945):747–754. doi: 10.1016/S0140-6736(14)60196-1. PMID: 24881994.（IF=202.731）
Sultana N, Zhang L, Yan J, Chen J, Cai W, Razzaque S, Jeong D, Sheng W, Bu L, Xu M, Huang GY, Hajjar RJ, Zhou B, Moon A, Cai CL. Resident C-Kit+ Cells in the Heart Are Not Cardiac Stem Cells. Nat Commun. 2015 Jan 27;6:8701. doi: 10.1038/ncomms9701. PMID: 26449133; PMCID: PMC4614564.（IF=17.694）

Doctor Profile

Dr. Guoying Huang

Pediatric Cardiology Professor · Chief Physician · Director · MD

Pediatric Cardiology

Non-invasive CHD

Integrated Care

Pediatric Screening

Experience

0 +yrs

0 +

papers

Authorized Patents

Expertise

Professional Background

SMA Treatment Cases

PART 1: Cases of Surgical Treatment For Severe Scoliosis

Female, 20 years old, severe spinal kyphoscoliosis with halo-pelvic traction

Correction rates: scoliosis 61.9% , kyphosis 40%

Blood transfusion: 300ml

Male, 27 years old, severe spinal kyphoscoliosis with halo-pelvic traction

Correction rates: scoliosis 22.5%, kyphosis 52.4%

Blood transfusion: 300ml

Female, 28 years old, severe spinal kyphoscoliosis with halo-pelvic traction

Correction rates: kyphosis 46.1%

Blood transfusion: 300ml

Female, 27 years old, severe spinal kyphoscoliosis with halo-pelvic traction

Correction rates: scoliosis 52.4%, kyphosis 50.0%

Blood transfusion: 600ml

PART 2: Cases of Surgical Treatment for Scoliosis Complicated with Rare Diseases

Indian patient, 13 years old, Stiff-Person Syndrome.
Post-op: scoliosis 38°, kyphosis 36°

Female, 22y

Weight 26.5kg

FVC=10.3%

FEV1=10.3%

Male, 21y

Type I SMA

Poor nutrition

FVC=14%

FEV1=14.3%

Female, 13y

Weight 23kg

Poor nutrition

PART 3: Cases of Surgical Treatment for Mild Scoliosis

Femael, 15 years old, Lenke 5 AIS, DVR correction LIV=L3, LIV≠L4 or L5

Male, 14 years old, Lenke 5 AIS, DVR correction LIV=L4, LIV≠L5

Female, 14 years old

LIV: CSVL+ (NT), Rot>II, Tilt>20°

Female, 16 years old

LIV: CSVL+ (NT), Rot>II, Tilt>25°

PART 4: Cases of Conservative Treatment for Scoliosis

Female, 12 yo, 2 years treatment, IBC 87.5%→133%,lumbar curve 40°→6° (cor rate 85%)

Male, 15 yo, 1.5 years treatment, IBC 117%→126%,thoraolumbar curve 42°→0° (cor rate 100%)

Female, 13 yo, 3 years treatment, IBC 50%→85%,

thoracic curve 40°→20° (cor rate 50%)

Female, 13 yo, 2y 3mons treatment, IBC 58.3%→81.3%,lumbar curve 48°→15° (cor rate 68.8%)

PART 4: Cases of Conservative Treatment for Scoliosis

Female, 12 yo, 2 years treatment, IBC 87.5%→133%,lumbar curve 40°→6° (cor rate 85%)

Male, 15 yo, 1.5 years treatment, IBC 117%→126%,thoraolumbar curve 42°→0° (cor rate 100%)

Female, 13 yo, 3 years treatment, IBC 50%→85%,

thoracic curve 40°→20° (cor rate 50%)

Female, 13 yo, 2y 3mons treatment, IBC 58.3%→81.3%,lumbar curve 48°→15° (cor rate 68.8%)

Awards & Honors

Advanced Individual of the National Health System

First Prize of Shanghai Science and Technology Progress Award

First Prize of Shanghai Teaching Achievement Award

Baosteel Excellent Teacher Award

Tan Jiazhen Clinical Medicine Award

Shanghai Mayor’s Quality Award

Outstanding Young and Middle-aged Expert with Significant Contributions, Ministry of Health of China

National Outstanding Healthcare Worker

Outstanding Hospital Director in China

China Pediatrician Award Recipient

Author of over 500 peer-reviewed articles in journals such as The Lancet, Annals of Internal Medicine, and Nature Communications

Author or co-author of 32 textbooks and monographs, holder of 23 patents

Mentor of more than 80 graduate students

Patient Reviews

[Anonymous] from Yunnan

2025-04-30

Rating:

Disease: Pediatric Congenital Scoliosis Description of Condition:

My child is six and a half years old, suffering from congenital hemivertebra at T10, with a scoliosis curvature of 25 degrees. Doctors in our hometown all recommended surgical treatment as soon as possible. We felt deeply distressed due to the child’s young age. Later, through a friend’s recommendation, we learned that Dr. Yang is a national expert in pediatric scoliosis. With a hopeful attitude, we came to Shanghai Xinhua Hospital.

Treatment Process:

First, we went to Dr. Yang’s assistant to check the quality of the imaging scans, confirming that re-scanning was unnecessary. Afterwards, we waited for Dr. Yang’s consultation. During this time, we encountered children from all over the country who had sought him out based on his reputation for scoliosis issues. It was 6:30 PM when it was finally our turn. Dr. Yang had already been consulting continuously for five hours. Yet, he patiently analyzed the child’s condition, earnestly answered our questions, determined that surgery was not necessary for the child, and taught the child postoperative rehabilitation exercises. The concept of “a healer’s benevolent heart” was embodied in this moment. We were deeply moved. Thank you, Dr. Yang!

More Reviews

[Anonymous] from Jiangsu

2025-03-06

Rating:

Disease:
Scoliosis

Treatment Process:

I am the child’s mother. When I first learned that my child had 44-degree scoliosis, my world instantly collapsed. This degree essentially met the surgical indication, potentially requiring surgery. At that time, I felt utterly helpless, and my daughter cried in fear right there in the consultation room. Anxiety and dread shadowed us during those days. As a parent, I blamed myself for not noticing the abnormality earlier and feared the condition might cause irreversible harm to my child; my heart was filled with pain. Fortunately, after much searching, we found Director Yang Junlin. At the first consultation, he inquired in detail about the child’s situation, meticulously reviewed every test report, explained the condition clearly and simply to us, and after a series of assessments, developed a customized treatment plan of “brace combined with physical therapy” for my child.

Recovery Situation:

The treatment process with brace and physical therapy was long and arduous. The child worked very hard and took it seriously. Every follow-up visit, every adjustment to the treatment plan – this year of treatment witnessed the child’s tears, my heartache as a mother, and Director Yang’s encouragement and affirmation. My daughter’s curvature decreased from the initial 44 degrees to 20 degrees. This is not merely a numerical change; it is the joy of the child regaining a healthy life. Director Yang, you are an angel in our child’s life. Thank you, Director Yang!

[Anonymous] from Shanxi

2025-02-28

Rating:

Disease:
Scoliosis
Description of Condition:

I am an SMA patient. Due to severe scoliosis compressing the heart and lungs, I experienced breathing difficulties and numbness on the left side of my body. For many years, I was unable to sit and could only lie down.

Treatment Process:

We learned about Director Yang from fellow patients and multimedia platforms, so we traveled from Shanxi to Shanghai to seek his help. After various preoperative examinations and discussions, as parents, we felt deeply conflicted. Such a major surgery carried significant risks, yet the doctors were taking these risks alongside our child. We had to proceed resolutely. When the surgery concluded, Director Yang emerged and announced its success. Seeing the look of exhaustion on his face, our hearts overflowed with gratitude. We thank the doctors for their superb surgical skills and their benevolent hearts! Your hard work and dedication have given our child a healthy life!

Recovery Status:

Postoperatively, the correction degree exceeded our expectations. Our child can now sit up and see the world from a seated position, bringing a fundamental change to daily life. Pulmonary function has also greatly improved.

[Anonymous] from Zhejiang

2024-04-11

Rating:

Disease:
Scoliosis

Description of Condition:

SMA onset at one year old. Initially able to walk with support but unable to walk independently. Condition worsened over time, leading to wheelchair use. Due to muscle atrophy, the upper body lacked support, followed by progressive scoliosis exceeding 180 degrees with prominent dorsal convexity.

Treatment Process:

Professor Yang is approachable and kind. With professional expertise in spinal medicine, he meticulously identified physical issues, demonstrating patience and clear communication!

Recovery Situation:

One-month post-surgery, independent wheelchair sitting duration reaches 6 hours. Self-feeding ability restored. Gradual recovery ongoing…

[Anonymous] from Shanghai

2023-10-11

Rating:

Disease:

Adult Scoliosis

Description of Condition:

Conservative treatment for adult scoliosis.

Treatment Process:

Smooth and efficient. Recovery Situation: I am 38 years old with a thoracic curve of 38 degrees and lumbar curve of 42 degrees. Unwilling to undergo surgery, I sought Professor Yang’s consultation. I am now wearing a brace. Though uncomfortable, I wish to attempt this approach to see if surgery can be avoided. This surgery is a lifelong commitment and a major operation. Thank you, Professor Yang, for being willing to provide me with an opportunity for conservative treatment.

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