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Dr. Guodong Li

Orthopedics

Professor · Chief Physician · Doctoral Supervisor · MD

Executive Director of the Departmentof Joint Recon & Sports Medicine, Shanghai Tenth People’s Hospital (the Tenth People’s Hospital Affiliated to Tongji University).

Orthopedic Expert

Joint Reconstruction

Arthroscopic Procedure

Bone Tumor Surgery

20+ yrs

Experience

5,000+

Minimally Invasive joint Replacements

 6,500+

Arthroscopic Procedures

Expertise

Specializes in minimally invasive knee and hip joint replacement, arthroscopic treatment of knee-shoulder-ankle sports injuries, and complex trauma / bone-tumor reconstruction. Has extensive clinical experience, with more than 5,000 minimally invasive joint replacements, 6,500 arthroscopic procedures, and 3,500 complex trauma surgeries performed. Also leads translational research into osteoarthritis mechanisms, nanomaterial cartilage repair, stem-cell therapy for cartilage defects, and molecular studies of osteosarcoma.

Professional Background

Dr. Li has been engaged in orthopedic clinical and research work for over 20 years, with a current focus on joint disorders (knee, hip, shoulder, ankle) and orthopedic oncology. His main research areas include:
  1. Clinical and translational research on osteoarthritis pathogenesis and repair mechanisms
  2. Nanomaterial-based cartilage regeneration technologies
  3. Stem-cell therapy and biologics for focal cartilage defects
  4. Molecular and clinical studies in osteosarcoma and other bone tumors
  5. Enhanced-Recovery-After-Surgery (ERAS) and AI-assisted navigation for joint replacement

He has independently performed more than 5,000 minimally invasive knee and hip joint-replacement surgeries, over 6,500 arthroscopic procedures for sports injuries, and more than 3,500 complex trauma and bone-tumor reconstructions, while overseeing upwards of 10,000 outpatient visits each year. An early pioneer of minimally invasive total knee arthroplasty in China, he continues to lead multi-center trials and nationwide training programs aimed at improving surgical outcomes and accelerating postoperative recovery.

Video Case Studies

Patient-centered Joint Surgery with Minimal-invasive Solutions

Medical Choice of NBA Star Family: The Doctor Who CuredYaoMing's ParentsJoint Disease

The Joint Expert Who Saved Chinese King of R&B's Performance Life

Advanced Surgical Techniques for Global Patients

Re Stand Up: A PE Teacher Rising from the Fall

Meticulously-Designed Surgery Makes Faster Recovery Solution to Rihanna's Case

Awards & Honors

  • “Silver Snake Award” recipient
  • Outstanding Academic Leaderappointed by the Shanghai MunicipalHealth Commission
  • First Prize, Chinese Medical Science and Technology Award
  • He has published over 100 academic papers, including 26 SCI-indexed articles with a cumulative impact factor over 82, and four papers with an individual IF of 5.17.

Recent Key Publications:

  1. Gao Q, Qiao Y, Guan Y, Zhang Y, Xu T, Duan Z, Fan L, Li Z, Li G, Sun J. Superior capsular reconstruction using the long head of the biceps to treat massive rotator cuff tears improves patients shoulder pain, mobility and function. Knee Surg Sports Traumatol Arthrosc. 2023 Oct;31(10):4559-4565. doi: 10.1007/s00167-023-07489-7. （IF=3.8）
  2. Zhang Y, Duan Z, Guan Y, Xu T, Fu Y, Li G. Identification of 3 key genes as novel diagnostic and therapeutic targets for OA and COVID-19. Front Immunol. 2023 May 22;14:1167639. doi: 10.3389/fimmu.2023.1167639. （IF=7.3）
  3. Lu H, Wei J, Liu K, et al. Radical-Scavenging and Subchondral Bone-Regenerating Nanomedicine for Osteoarthritis Treatment [published online ahead of print, 2023 Mar 15]. ACS Nano. 2023;10.1021/acsnano.3c01789. doi:10.1021/acsnano.3c01789 （IF=18.027）
  4. Li Z, Duan Z, Jia K, Yao Y, Liu K, Qiao Y, Gao Q, Yang Y, Li G, Shang A. A Combined Risk Score Model to Assess Prognostic Value in Patients with Soft Tissue Sarcomas. Cells. 2022 Dec 16;11(24):4077. doi: 10.3390/cells11244077. （IF=6）
  5. Xu T, Yang D, Liu K, Gao Q, Liu Z, Li G. Miya Improves Osteoarthritis Characteristics via the Gut-Muscle-Joint Axis According to Multi-Omics Analyses. Front Pharmacol. 2022;13:816891. Published 2022 May 20. doi:10.3389/fphar.2022.816891（IF=5.988）
  6. Liu K, Liao Y, Zhou Z, et al. Photothermal-triggered immunogenic nanotherapeutics for optimizing osteosarcoma therapy by synergizing innate and adaptive immunity. Biomaterials. 2022;282:121383. doi:10.1016/j.biomaterials.2022.121383（IF=15.304）
  7. Liu K, Liao Y, Yang D, et al. Influence of Patella Position on Soft Tissue Balance and Clinical Outcomes in Patients Undergoing Minimally Invasive Total Knee Arthroplasty, a Randomized Clinical Trial. Front Surg. 2022;9:692072. Published 2022 Feb 4. doi:10.3389/fsurg.2022.692072（IF=2.568）
  8. Xu T, Yang D, Liu K, et al. Efficacy and safety of a self-developed home-based enhanced knee flexion exercise program compared with standard supervised physiotherapy to improve mobility and quality of life after total knee arthroplasty: a randomized control study. J Orthop Surg Res. 2021;16(1):382. Published 2021 Jun 14. doi:10.1186/s13018-021-02516-0（IF=2.677）
  9. Yang D, Liu K, Fan L, Xu T, Li G. Closed suction drainage offers no more clinical benefit than non-drainage after primary total knee arthroplasty with the administration of tranexamic acid in Chinese patients. Arthroplasty. 2020;2(1):18. Published 2020 Jun 23. doi:10.1186/s42836-020-00035-7（IF=0.22）
  10. Liu K, Yang D, Zan P, et al. Preoperative low scores of Life Satisfaction Rating predicts poor outcomes after total knee arthroplasty: a prospective observational study. J Orthop Surg Res. 2020;15(1):145. Published 2020 Apr 15. doi:10.1186/s13018-020-01668-9 （IF=2.677）
  11. Yang Dong,Liu Kaiyuan,Fan Lin,Liang Wenqing,Xu Tianyang,Jiang Wenwei,Lu Hengli,Jiang Junjie,Wang Chi,Li Guodong. LncRNA RP11-361F15.2 promotes osteosarcoma tumorigenesis by inhibiting M2-Like polarization of tumor-associated macrophages of CPEB4.[J] .Cancer Lett., 2020, 473: 33-49. （IF=9.756）
  12. Tianyang Xu, Lin Fan, Zhi Zheng, Guodong Li.Efficacy and safety of low stool assisted standardized home exercise program comparing supervised physiotherapy to improve mobility and quality of life after Total knee arthroplasty. Med Sci Monit.（IF=1.585）
  13. Liu K, Yang D, Fan L, Jiang W, Fan A, Xu T, Li G. Low Scores of Life Satisfaction Rating Predicts Dissatisfaction of Total Knee Arthroplasty. Orthrpaedic Surgery.(IF=1.147)
  14. Fan L, Lin C, Zhao P, Wen X, Li G. An Injectable Bioorthogonal Dextran Hydrogel for Enhanced Chondrogenesis of Primary Stem Cells. Tissue Eng Part C Methods. 2018;24(9):504-513. doi:10.1089/ten.TEC.2018.0085.(IF=4.71)
  15. P.Zan,M.O.Mol,J.J.Yao,L.Fan,D.Yang,K.Liu,G.Li. Release of the tourniquet immediately after the implantation of the components reduces the incidence of deep vein thrombosis after primary total knee arthroplasty. Bone Joint Res. 2017 Sep:vol 6:535-541.(IF=3.652)
  16. Zan P, Fan L, Liu K, Yang Y, Hu S, Li G. Reduction Osteotomy versus Extensive Release on Clinical Outcome Measures in Simultaneous Bilateral Total Knee Arthroplasty. Med Sci Monit. 2017 Aug 7;23:3817-3823.（IF=1.98）
  17. Zan P, Yao JJ, Fan L, Yang Y, Zhou Z, Wu Z, Zhu C, Yang D, Li G. Efficacy of a Four-Hour Drainage Clamping Technique in the Reduction of Blood Loss Following Total Hip Arthroplasty: A Prospective Cohort Study. Med Sci Monit. 2017 Jun 3;23:2708-2714.（IF=1.98）
  18. Zan PF, Yao J, Wu Z, Yang Y, Hu S, Li GD. Cyclin D1 Gene Silencing Promotes IL-1β-Induced Apoptosis in Rat Chondrocytes. J Cell Biochem. 2017 May 26. doi: 10.1002/jcb.26172. (IF=3.448)
  19. Lin F,Chunyan Zhu,Rongmin Qiu,Pengfei Zan,Zhi Zheng,Tianyang Xu,Guodong Li. Micro-RNA-661 Enhances TRAIL or STS Induced Osteosarcoma Cell Apoptosis by Modulating the Expression of Cytochrome C1.Cellular Physiology and Biochemistry.2017;41:.(IF=5.5)
  20. Zan P, Wang W, Fan L, et al. Closed-suction drainage versus no drainage in total hip arthroplasty, a meta-analysis of randomized controlled trials. Int J Clin Exp Med. 2016;9(2):725-735. (IF=1.277)
  21. Fan L, Yu X, Zan P, Liu J, Ji T, Li G. Comparison of Local Infiltration Analgesia With Femoral Nerve Block for Total Knee Arthroplasty: A Prospective, Randomized Clinical Trial. J Arthroplasty. Jun 2016;31(6):1361-1365. (IF=3.524)
  22. Zan P, Wu Z, Yu X, Fan L, Xu T, Li G. The Effect of Patella Eversion on Clinical Outcome Measures in Simultaneous Bilateral Total Knee Arthroplasty: A Prospective Randomized Controlled Trial. J Arthroplasty. Mar 2016;31(3):637-640. (IF=3.524)
  23. Fan, L., C. Zhu, P. Zan, X. Yu, J. Liu, Q. Sun and G. Li . “The Comparison of Local Infiltration Analgesia With Peripheral Nerve Block Following TKA: A System Review With Meta-Analysis.” J Arthroplasty.2015 Sep;30(9):1664-71 (IF=3.524)
  24. Zan, P. F., Y. Yang, D. Fu, X. Yu and G. D. Li . Releasing of Tourniquet Before Wound Closure or not in Total Knee Arthroplasty: A Meta-Analysis of Randomized Controlled Trials.”J Arthroplasty.2015 Mar;30(1): 31-37. (IF=3.524)
  25. Zan, P. F., W. Sun, Y. Yang, X. Y. Cai, X. J. Ma and G. D. Li (2015). “No difference in clinical outcome between patella eversion and lateral retraction in total knee arthroplasty: a systemic review and meta-analysis.” Knee Surgery Sports Traumatology Arthroscopy 23(6): 1791-1798.(IF=3.23)
  26. Chen, K.，Zhu, C.，Cai, M.，Fu, D.，Cheng, B.，Cai, Z.，Li, G.，Liu, J. Integrative metabolome and transcriptome profiling reveals discordant glycolysis process between osteosarcoma and normal osteoblastic cells. J Cancer Res ClinOncol, 2014. 140(10): p. 1715-21 (IF=3.332)
  27. Li G, Fu D, Liang W, Fan L, Chen K, Shan L, Hu S, Ma X, Zhou K, Cheng B, CYC1 Silencing Sensitizes Osteosarcoma Cells to TRAIL-Induced Apoptosis. Cell Physiol Biochem 2014;34:2070-2080. (IF=5.5)
  28. Chen Kai, Li Guodong, Fu Dong, Yuan Chaoqun, Zhang Qiang, CaiZhengdong. Patellar resurfacing versus nonresurfacing in total knee arthroplasty: A meta-analysis of randomised controlled trials. IntOrthop. 2013 Jun;37(6):1075-83. (IF=2.384)
  29. Dong Fu, Guodong Li, Kai Chen, Yiqiong Zhao, YingqiHua, ZhengdongCai. Comparison of High Tibial Osteotomy and Unicompartmental Knee Arthroplasty in the Treatment of Unicompartmental Osteoarthritis: A Meta-Analysis. J Arthroplasty. 2013 May;28(5):759-65.(IF=3.524)
  30. Dong Fu, Guodong Li, ZhengdongCai. Comparison of Clinical Outcome Between Simultaneous-Bilateral and Staged-Bilateral Total Knee Arthroplasty: A Systematic review of Retrospective Studies. J Arthroplasty. 2013 Aug;28(7):1141-7. (IF=3.524)
  31. Ma Xiaojun, Li Guodong, CaiZhengdong, Sun Wei, Liu Junjian, Zhang Fan. Leukemoid reaction in malignant bone tumor patients – a retrospective, single-institution study. Eur Rev Med PharmacolSci. 2012 Dec;16(14):1895-9. (IF=2.721)
  32. Guodong Li, Dong Fu, ZhengdongCai. Surgical strategy for the management of sacral giant cell tumors: a 32-case series. Spine J. 2012 Jun;12(6):484-91. (IF=3.333）
  33. Guodong Li, Ming Cai, ZhengdongCai, Biao Cheng. Heat Shock Protein 90B1 Plays an Oncogenic Role and is a Target of microRNA-223 in Human Osteosarcoma. Cell Physiol Biochem,2012;30:1481-1490. (IF=5.5)
  34. Li Guodong, Chen Kai, Fu Dong, Ma Xiaojun, Sun Mengxiong, Sun Wei, *CaiZhengdong. Clinical experience: Surgical strategy for presacral tumors: analysis of 33 cases. Chin Med J 2011;124(23):4086-4091. (IF=1.555)
  35. Li, G., W. Zhang, H. Zeng, L. Chen, W. Wang, J. Liu, Z. Zhang and *Z. Cai. An integrative multi-platform analysis for discovering biomarkers of osteosarcoma. BMC, 2009, 9:150 doi:10.1186/1471-2407-9-150. (IF=3.33)

Patient Reviews

[Anonymous] from Shanghai

2024.05.11

Disease:
Artificial Left Knee Joint Replacement Surgery

Description of Condition:

Two years ago, my mother began experiencing pain in her left knee. In the latter half of last year, walking became somewhat difficult. Early this year, during a check-up with Dr. Li, he recommended artificial left knee joint replacement surgery to restore normal life. This time, my 81-year-old mother hesitated because my father, who suffered a cerebral infarction and cannot walk, now lives in a nursing home. Additionally, as her son residing abroad, I cannot return long-term to accompany her through surgery and recovery.

Treatment Process:

Upon learning of this situation, Dr. Li explained the required hospitalization duration and postoperative recovery period. He also scheduled the surgery according to my return timeframe. Dr. Li personally performed this artificial left knee joint replacement surgery, which was again highly successful. The surgery took place on the morning of April 23.

Recovery Situation:

The next afternoon, my mother could walk with a walker; on the third day, she walked with my support; on the fourth day, she used a rehabilitation bicycle. On the sixth postoperative day (April 28), my mother was smoothly discharged. After several days of recovery and training, by May 2, she could walk independently without support or a walker. As of today, May 11, she has essentially returned to normal and can manage daily life independently.
I also researched the required duration for artificial left knee joint replacement surgery in Japan, where I reside. In Japan, unilateral artificial left knee joint replacement surgery requires 2–3 weeks of hospitalization, with independent daily living taking over 4 weeks. In contrast, my mother’s hospitalization lasted only 1 week, and she achieved independent daily living within 3 weeks post-surgery.

[Anonymous] from Shanxi

2024.03.16

Disease:
Hip Replacement Surgery

Description of Condition:

The patient is my 90-year-old mother. In December 2023, she accidentally fell at home, resulting in a femoral neck fracture. The treating hospital struggled to finalize a surgical plan due to her comorbid heart failure (with cardiac markers exceeding 10,000) and severe osteoporosis. However, the patient could not wait any longer. Our family immediately contacted Dr. Li Guodong at Shanghai Tenth People’s Hospital. Dr. Li thoroughly and patiently addressed all our concerns. His statement—”Professional matters require finding the right professional doctor; leave it to the experts”—instilled confidence in our entire family.

Treatment Process:

We transferred to his hospital the next day. Following Dr. Li’s masterful 30-minute surgery and meticulous hospital care:

Recovery Situation:

My mother stood up within 3 days post-surgery. Now, after just over 2 months, she can walk approximately 50 meters without a walker. We extend our deepest gratitude to Dr. Li—”With miraculous hands and benevolent heart, he showcases excellence; with masterful skill and compassion, he mends broken bones.” A truly boundless healer!

[Anonymous] from Zhejiang

2024.03.12

Disease:
Minimally invasive joint surgery

Description of Condition:

The right joint was swollen and severely deformed. The pain has persisted for over ten years. Difficulty in walking even caused me to feel mentally disoriented, among other issues.

Treatment Process:

Recommended by a classmate. I’m from Melbourne, Australia. I gave up years of waiting in line locally and came to Shanghai Tenth People’s Hospital for surgery performed by Director Li Guodong.

Recovery Situation:

After being discharged, under the guidance of Director Li’s team, my recovery has been excellent. I’m very satisfied with the outcome.

[Anonymous] from Zhejiang

2023.11.01

Disease:
Total Knee Replacement Surgery for Both Sides

Description of Condition:

Both of my knees had been painfully swollen and severely deformed for over a decade.

Treatment Process:

Admitted to the hospital the same day. Diagnosis confirmed the need for double knee replacement, and surgery was performed in the afternoon. Seven days later, the second knee replacement was done.

Recovery Situation:

After the first knee surgery, I could walk with the second leg. After the second knee surgery, the recovery was similar to the first. Now, following the rehabilitation training guided by Dr. Li, I can walk freely with both legs.

[Anonymous] from Yunnan

2023.01.22

Disease:
Rotator Cuff Minimally Invasive Surgery

Description of Condition:

In June 2022, due to pain, I had an MRI at a local hospital and was diagnosed with a rotator cuff tear. The doctor prescribed painkillers and recommended conservative treatment. While taking the medicine, I also applied plasters and did moxibustion, but the effect was not obvious, and the pain persisted. On November 24th, I went to another local hospital for an MRI, which diagnosed a rotator cuff injury. They performed an intra – articular injection as treatment, but the pain worsened as the Spring Festival approached. I woke up several times at night due to the pain and really couldn’t fall asleep! Through a friend’s recommendation, I got in touch with Dr. Li.

Treatment Process:

After Dr. Li reviewed my MRI images online, he immediately diagnosed that bone spurs had caused acromion impingement, leading to a rotator cuff tendon tear, and that minimally invasive surgery could be performed! With Dr. Li’s patient explanations and guidance, I had an in – person consultation with him on January 16, 2023. After that, I completed the hospital admission procedures, and the surgery was scheduled the next day.

Recovery Situation:

On the third day, I could start climbing the wall with my post – operative arm under the doctor’s guidance! Today is the fifth day after my surgery, and I can clearly feel that my recovery is getting better and better. By sticking to wall – climbing exercises every day, my progress is very remarkable! The range of motion of my arm is vastly different from before the surgery! My life is full of hope again! Looking back on my medical journey, I feel extremely fortunate to have met Dr. Li! I am grateful to Teacher Gu who recommended Dr. Li to me, and to Dr. Li and his team. Their exquisite skills, humble demeanor, and patient, meticulous guidance gave me the courage to face the surgery, motivated me to actively exercise after the surgery, and helped me regain my health!

[Anonymous] from Jiangsu

2023.01.22

Disease:
Hip Replacement Surgery

Description of Condition:

I have been suffering from hip joint pain and difficulty walking for a long time. Three years ago, I was diagnosed with avascular necrosis of the femoral head. I was afraid of surgery, so I kept putting it off. Recently, I really couldn’t walk anymore, so as a last resort, I found Director Li through a recommendation.

Treatment Process:

After looking at my X-rays, he immediately admitted me to the hospital and reassured me, saying that hip replacement surgery is very mature and minimally invasive, so I shouldn’t be afraid, and that he would perform the surgery! The surgery was on September 1st, and I was discharged home on the 7th, with no pain throughout. On the first day after surgery, I got out of bed and took a few steps, and on the second day, I used the toilet with the caregiver’s assistance.

Recovery Situation:

Now I’m recuperating at home. I can walk with the help of assistive devices, get out of bed and go to the toilet on my own. I will have a follow-up visit in 2 weeks. Director Li Guodong is anxious to address patients’ urgency, relieves patients’ pain, always puts patients first, and is an excellent doctor with superb medical skills!

Contact Us

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Doctor Profile

Dr. Guodong Li

Orthopedics
Professor · Chief Physician · Doctoral Supervisor · MD`

Orthopedic Expert
Joint Reconstruction
Arthroscopic Procedure
Bone Tumor Surgery
Executive Director of the Departmentof Joint Recon & Sports Medicine, Shanghai Tenth People’s Hospital (the Tenth People’s Hospital Affiliated to Tongji University).

Experience

0 +yrs
0 +

Minimally Invasive joint Replacements

0 +

Arthroscopic Procedures

Second Opinion ＄399

Contact Me

Expertise

Specializes in minimally invasive knee and hip joint replacement, arthroscopic treatment of knee-shoulder-ankle sports injuries, and complex trauma / bone-tumor reconstruction. Has extensive clinical experience, with more than 5,000 minimally invasive joint replacements, 6,500 arthroscopic procedures, and 3,500 complex trauma surgeries performed. Also leads translational research into osteoarthritis mechanisms, nanomaterial cartilage repair, stem-cell therapy for cartilage defects, and molecular studies of osteosarcoma.

Professional Background

Dr. Li has been engaged in orthopedic clinical and research work for over 20 years, with a current focus on joint disorders (knee, hip, shoulder, ankle) and orthopedic oncology. His main research areas include:
  1. Clinical and translational research on osteoarthritis pathogenesis and repair mechanisms
  2. Nanomaterial-based cartilage regeneration technologies
  3. Stem-cell therapy and biologics for focal cartilage defects
  4. Molecular and clinical studies in osteosarcoma and other bone tumors
  5. Enhanced-Recovery-After-Surgery (ERAS) and AI-assisted navigation for joint replacement
He has independently performed more than 5,000 minimally invasive knee and hip joint-replacement surgeries, over 6,500 arthroscopic procedures for sports injuries, and more than 3,500 complex trauma and bone-tumor reconstructions, while overseeing upwards of 10,000 outpatient visits each year. An early pioneer of minimally invasive total knee arthroplasty in China, he continues to lead multi-center trials and nationwide training programs aimed at improving surgical outcomes and accelerating postoperative recovery.

Case Videos

Patient-centered Joint Surgery with Minimal-invasive Solutions

Re Stand Up: A PE Teacher Rising from the Fall

Meticulously-Designed Surgery Makes Faster Recovery Solution to Rihanna's Case

Advanced Surgical Techniques for Global Patients

Medical Choice of NBA Star Family: The Doctor Who CuredYaoMing's ParentsJoint Disease

The Joint Expert Who Saved Chinese King of R&B's Performance Life

Awards & Honors

“Silver Snake Award” recipient

Outstanding Academic Leaderappointed by the Shanghai MunicipalHealth Commission

First Prize, Chinese Medical Science and Technology Award

He has published over 100 academic papers, including 26 SCI-indexed articles with a cumulative impact factor over 82, and four papers with an individual IF of 5.17.

Recent Key Publications:

  1. Gao Q, Qiao Y, Guan Y, Zhang Y, Xu T, Duan Z, Fan L, Li Z, Li G, Sun J. Superior capsular reconstruction using the long head of the biceps to treat massive rotator cuff tears improves patients shoulder pain, mobility and function. Knee Surg Sports Traumatol Arthrosc. 2023 Oct;31(10):4559-4565. doi: 10.1007/s00167-023-07489-7. （IF=3.8）
  2. Zhang Y, Duan Z, Guan Y, Xu T, Fu Y, Li G. Identification of 3 key genes as novel diagnostic and therapeutic targets for OA and COVID-19. Front Immunol. 2023 May 22;14:1167639. doi: 10.3389/fimmu.2023.1167639. （IF=7.3）
  3. Lu H, Wei J, Liu K, et al. Radical-Scavenging and Subchondral Bone-Regenerating Nanomedicine for Osteoarthritis Treatment [published online ahead of print, 2023 Mar 15]. ACS Nano. 2023;10.1021/acsnano.3c01789. doi:10.1021/acsnano.3c01789 （IF=18.027）
  4. Li Z, Duan Z, Jia K, Yao Y, Liu K, Qiao Y, Gao Q, Yang Y, Li G, Shang A. A Combined Risk Score Model to Assess Prognostic Value in Patients with Soft Tissue Sarcomas. Cells. 2022 Dec 16;11(24):4077. doi: 10.3390/cells11244077. （IF=6）
  5. Xu T, Yang D, Liu K, Gao Q, Liu Z, Li G. Miya Improves Osteoarthritis Characteristics via the Gut-Muscle-Joint Axis According to Multi-Omics Analyses. Front Pharmacol. 2022;13:816891. Published 2022 May 20. doi:10.3389/fphar.2022.816891（IF=5.988）
  6. Liu K, Liao Y, Zhou Z, et al. Photothermal-triggered immunogenic nanotherapeutics for optimizing osteosarcoma therapy by synergizing innate and adaptive immunity. Biomaterials. 2022;282:121383. doi:10.1016/j.biomaterials.2022.121383（IF=15.304）
  7. Liu K, Liao Y, Yang D, et al. Influence of Patella Position on Soft Tissue Balance and Clinical Outcomes in Patients Undergoing Minimally Invasive Total Knee Arthroplasty, a Randomized Clinical Trial. Front Surg. 2022;9:692072. Published 2022 Feb 4. doi:10.3389/fsurg.2022.692072（IF=2.568）
  8. Xu T, Yang D, Liu K, et al. Efficacy and safety of a self-developed home-based enhanced knee flexion exercise program compared with standard supervised physiotherapy to improve mobility and quality of life after total knee arthroplasty: a randomized control study. J Orthop Surg Res. 2021;16(1):382. Published 2021 Jun 14. doi:10.1186/s13018-021-02516-0（IF=2.677）
  9. Yang D, Liu K, Fan L, Xu T, Li G. Closed suction drainage offers no more clinical benefit than non-drainage after primary total knee arthroplasty with the administration of tranexamic acid in Chinese patients. Arthroplasty. 2020;2(1):18. Published 2020 Jun 23. doi:10.1186/s42836-020-00035-7（IF=0.22）
  10. Liu K, Yang D, Zan P, et al. Preoperative low scores of Life Satisfaction Rating predicts poor outcomes after total knee arthroplasty: a prospective observational study. J Orthop Surg Res. 2020;15(1):145. Published 2020 Apr 15. doi:10.1186/s13018-020-01668-9 （IF=2.677）
  11. Yang Dong,Liu Kaiyuan,Fan Lin,Liang Wenqing,Xu Tianyang,Jiang Wenwei,Lu Hengli,Jiang Junjie,Wang Chi,Li Guodong. LncRNA RP11-361F15.2 promotes osteosarcoma tumorigenesis by inhibiting M2-Like polarization of tumor-associated macrophages of CPEB4.[J] .Cancer Lett., 2020, 473: 33-49. （IF=9.756）
  12. Tianyang Xu, Lin Fan, Zhi Zheng, Guodong Li.Efficacy and safety of low stool assisted standardized home exercise program comparing supervised physiotherapy to improve mobility and quality of life after Total knee arthroplasty. Med Sci Monit.（IF=1.585）
  13. Liu K, Yang D, Fan L, Jiang W, Fan A, Xu T, Li G. Low Scores of Life Satisfaction Rating Predicts Dissatisfaction of Total Knee Arthroplasty. Orthrpaedic Surgery.(IF=1.147)
  14. Fan L, Lin C, Zhao P, Wen X, Li G. An Injectable Bioorthogonal Dextran Hydrogel for Enhanced Chondrogenesis of Primary Stem Cells. Tissue Eng Part C Methods. 2018;24(9):504-513. doi:10.1089/ten.TEC.2018.0085.(IF=4.71)
  15. P.Zan,M.O.Mol,J.J.Yao,L.Fan,D.Yang,K.Liu,G.Li. Release of the tourniquet immediately after the implantation of the components reduces the incidence of deep vein thrombosis after primary total knee arthroplasty. Bone Joint Res. 2017 Sep:vol 6:535-541.(IF=3.652)
  16. Zan P, Fan L, Liu K, Yang Y, Hu S, Li G. Reduction Osteotomy versus Extensive Release on Clinical Outcome Measures in Simultaneous Bilateral Total Knee Arthroplasty. Med Sci Monit. 2017 Aug 7;23:3817-3823.（IF=1.98）
  17. Zan P, Yao JJ, Fan L, Yang Y, Zhou Z, Wu Z, Zhu C, Yang D, Li G. Efficacy of a Four-Hour Drainage Clamping Technique in the Reduction of Blood Loss Following Total Hip Arthroplasty: A Prospective Cohort Study. Med Sci Monit. 2017 Jun 3;23:2708-2714.（IF=1.98）
  18. Zan PF, Yao J, Wu Z, Yang Y, Hu S, Li GD. Cyclin D1 Gene Silencing Promotes IL-1β-Induced Apoptosis in Rat Chondrocytes. J Cell Biochem. 2017 May 26. doi: 10.1002/jcb.26172. (IF=3.448)
  19. Lin F,Chunyan Zhu,Rongmin Qiu,Pengfei Zan,Zhi Zheng,Tianyang Xu,Guodong Li. Micro-RNA-661 Enhances TRAIL or STS Induced Osteosarcoma Cell Apoptosis by Modulating the Expression of Cytochrome C1.Cellular Physiology and Biochemistry.2017;41:.(IF=5.5)
  20. Zan P, Wang W, Fan L, et al. Closed-suction drainage versus no drainage in total hip arthroplasty, a meta-analysis of randomized controlled trials. Int J Clin Exp Med. 2016;9(2):725-735. (IF=1.277)
  21. Fan L, Yu X, Zan P, Liu J, Ji T, Li G. Comparison of Local Infiltration Analgesia With Femoral Nerve Block for Total Knee Arthroplasty: A Prospective, Randomized Clinical Trial. J Arthroplasty. Jun 2016;31(6):1361-1365. (IF=3.524)
  22. Zan P, Wu Z, Yu X, Fan L, Xu T, Li G. The Effect of Patella Eversion on Clinical Outcome Measures in Simultaneous Bilateral Total Knee Arthroplasty: A Prospective Randomized Controlled Trial. J Arthroplasty. Mar 2016;31(3):637-640. (IF=3.524)
  23. Fan, L., C. Zhu, P. Zan, X. Yu, J. Liu, Q. Sun and G. Li . “The Comparison of Local Infiltration Analgesia With Peripheral Nerve Block Following TKA: A System Review With Meta-Analysis.” J Arthroplasty.2015 Sep;30(9):1664-71 (IF=3.524)
  24. Zan, P. F., Y. Yang, D. Fu, X. Yu and G. D. Li . Releasing of Tourniquet Before Wound Closure or not in Total Knee Arthroplasty: A Meta-Analysis of Randomized Controlled Trials.”J Arthroplasty.2015 Mar;30(1): 31-37. (IF=3.524)
  25. Zan, P. F., W. Sun, Y. Yang, X. Y. Cai, X. J. Ma and G. D. Li (2015). “No difference in clinical outcome between patella eversion and lateral retraction in total knee arthroplasty: a systemic review and meta-analysis.” Knee Surgery Sports Traumatology Arthroscopy 23(6): 1791-1798.(IF=3.23)
  26. Chen, K.，Zhu, C.，Cai, M.，Fu, D.，Cheng, B.，Cai, Z.，Li, G.，Liu, J. Integrative metabolome and transcriptome profiling reveals discordant glycolysis process between osteosarcoma and normal osteoblastic cells. J Cancer Res ClinOncol, 2014. 140(10): p. 1715-21 (IF=3.332)
  27. Li G, Fu D, Liang W, Fan L, Chen K, Shan L, Hu S, Ma X, Zhou K, Cheng B, CYC1 Silencing Sensitizes Osteosarcoma Cells to TRAIL-Induced Apoptosis. Cell Physiol Biochem 2014;34:2070-2080. (IF=5.5)
  28. Chen Kai, Li Guodong, Fu Dong, Yuan Chaoqun, Zhang Qiang, CaiZhengdong. Patellar resurfacing versus nonresurfacing in total knee arthroplasty: A meta-analysis of randomised controlled trials. IntOrthop. 2013 Jun;37(6):1075-83. (IF=2.384)
  29. Dong Fu, Guodong Li, Kai Chen, Yiqiong Zhao, YingqiHua, ZhengdongCai. Comparison of High Tibial Osteotomy and Unicompartmental Knee Arthroplasty in the Treatment of Unicompartmental Osteoarthritis: A Meta-Analysis. J Arthroplasty. 2013 May;28(5):759-65.(IF=3.524)
  30. Dong Fu, Guodong Li, ZhengdongCai. Comparison of Clinical Outcome Between Simultaneous-Bilateral and Staged-Bilateral Total Knee Arthroplasty: A Systematic review of Retrospective Studies. J Arthroplasty. 2013 Aug;28(7):1141-7. (IF=3.524)
  31. Ma Xiaojun, Li Guodong, CaiZhengdong, Sun Wei, Liu Junjian, Zhang Fan. Leukemoid reaction in malignant bone tumor patients – a retrospective, single-institution study. Eur Rev Med PharmacolSci. 2012 Dec;16(14):1895-9. (IF=2.721)
  32. Guodong Li, Dong Fu, ZhengdongCai. Surgical strategy for the management of sacral giant cell tumors: a 32-case series. Spine J. 2012 Jun;12(6):484-91. (IF=3.333）
  33. Guodong Li, Ming Cai, ZhengdongCai, Biao Cheng. Heat Shock Protein 90B1 Plays an Oncogenic Role and is a Target of microRNA-223 in Human Osteosarcoma. Cell Physiol Biochem,2012;30:1481-1490. (IF=5.5)
  34. Li Guodong, Chen Kai, Fu Dong, Ma Xiaojun, Sun Mengxiong, Sun Wei, *CaiZhengdong. Clinical experience: Surgical strategy for presacral tumors: analysis of 33 cases. Chin Med J 2011;124(23):4086-4091. (IF=1.555)
  35. Li, G., W. Zhang, H. Zeng, L. Chen, W. Wang, J. Liu, Z. Zhang and *Z. Cai. An integrative multi-platform analysis for discovering biomarkers of osteosarcoma. BMC, 2009, 9:150 doi:10.1186/1471-2407-9-150. (IF=3.33)

Patient Reviews

[Anonymous] from Shanxi

2024.05.11

Rating:

Treatment Process:
Upon learning of this situation, Dr. Li explained the required hospitalization duration and postoperative recovery period. He also scheduled the surgery according to my return timeframe. Dr. Li personally performed this artificial left knee joint replacement surgery, which was again highly successful. The surgery took place on the morning of April 23.
Recovery Status:
The next afternoon, my mother could walk with a walker; on the third day, she walked with my support; on the fourth day, she used a rehabilitation bicycle. On the sixth postoperative day (April 28), my mother was smoothly discharged. After several days of recovery and training, by May 2, she could walk independently without support or a walker. As of today, May 11, she has essentially returned to normal and can manage daily life independently. I also researched the required duration for artificial left knee joint replacement surgery in Japan, where I reside. In Japan, unilateral artificial left knee joint replacement surgery requires 2–3 weeks of hospitalization, with independent daily living taking over 4 weeks. In contrast, my mother’s hospitalization lasted only 1 week, and she achieved independent daily living within 3 weeks post-surgery.
Surgery: Artificial Left Knee Joint Replacement Surgery Description of Condition:
Two years ago, my mother began experiencing pain in her left knee. In the latter half of last year, walking became somewhat difficult. Early this year, during a check-up with Dr. Li, he recommended artificial left knee joint replacement surgery to restore normal life. This time, my 81-year-old mother hesitated because my father, who suffered a cerebral infarction and cannot walk, now lives in a nursing home. Additionally, as her son residing abroad, I cannot return long-term to accompany her through surgery and recovery.

[Anonymous] from Shanxi

2024.03.16

Rating:

Surgery: Hip Replacement Surgery Description of Condition:
The patient is my 90-year-old mother. In December 2023, she accidentally fell at home, resulting in a femoral neck fracture. The treating hospital struggled to finalize a surgical plan due to her comorbid heart failure (with cardiac markers exceeding 10,000) and severe osteoporosis. However, the patient could not wait any longer. Our family immediately contacted Dr. Li Guodong at Shanghai Tenth People’s Hospital. Dr. Li thoroughly and patiently addressed all our concerns. His statement—”Professional matters require finding the right professional doctor; leave it to the experts”—instilled confidence in our entire family.
Treatment Process:
We transferred to his hospital the next day. Following Dr. Li’s masterful 30-minute surgery and meticulous hospital care:
Recovery Status:
My mother stood up within 3 days post-surgery. Now, after just over 2 months, she can walk approximately 50 meters without a walker. We extend our deepest gratitude to Dr. Li—”With miraculous hands and benevolent heart, he showcases excellence; with masterful skill and compassion, he mends broken bones.” A truly boundless healer!

[Anonymous] from Shanxi

2024.03.16

Rating:

Surgery: Minimally invasive joint surgery Description of Condition:
The right joint was swollen and severely deformed. The pain has persisted for over ten years. Difficulty in walking even caused me to feel mentally disoriented, among other issues.
Treatment Process:
Recommended by a classmate. I’m from Melbourne, Australia. I gave up years of waiting in line locally and came to Shanghai Tenth People’s Hospital for surgery performed by Director Li Guodong.
Recovery Status:
After being discharged, under the guidance of Director Li’s team, my recovery has been excellent. I’m very satisfied with the outcome.

[Anonymous] from Shanxi

2023.09.12

Rating:

Surgery: Hip Replacement Surgery Description of Condition:
I have been suffering from hip joint pain and difficulty walking for a long time. Three years ago, I was diagnosed with avascular necrosis of the femoral head. I was afraid of surgery, so I kept putting it off. Recently, I really couldn’t walk anymore, so as a last resort, I found Director Li through a recommendation.
Treatment Process:
After looking at my X-rays, he immediately admitted me to the hospital and reassured me, saying that hip replacement surgery is very mature and minimally invasive, so I shouldn’t be afraid, and that he would perform the surgery! The surgery was on September 1st, and I was discharged home on the 7th, with no pain throughout. On the first day after surgery, I got out of bed and took a few steps, and on the second day, I used the toilet with the caregiver’s assistance.
Recovery Status:
Now I’m recuperating at home. I can walk with the help of assistive devices, get out of bed and go to the toilet on my own. I will have a follow-up visit in 2 weeks. Director Li Guodong is anxious to address patients’ urgency, relieves patients’ pain, always puts patients first, and is an excellent doctor with superb medical skills!

[Anonymous] from Shanxi

2023.11.01

Rating:

Surgery:
Total Knee Replacement Surgery for Both Sides
Description of Condition:

Both of my knees had been painfully swollen and severely deformed for over a decade.

Treatment Process:
Admitted to the hospital the same day. Diagnosis confirmed the need for double knee replacement, and surgery was performed in the afternoon. Seven days later, the second knee replacement was done.
Recovery Status:
After the first knee surgery, I could walk with the second leg. After the second knee surgery, the recovery was similar to the first. Now, following the rehabilitation training guided by Dr. Li, I can walk freely with both legs.

[Anonymous] from Yunnan

2023.01.22

Rating:

Surgery: Rotator Cuff Minimally Invasive Surgery Description of Condition:
In June 2022, due to pain, I had an MRI at a local hospital and was diagnosed with a rotator cuff tear. The doctor prescribed painkillers and recommended conservative treatment. While taking the medicine, I also applied plasters and did moxibustion, but the effect was not obvious, and the pain persisted. On November 24th, I went to another local hospital for an MRI, which diagnosed a rotator cuff injury. They performed an intra – articular injection as treatment, but the pain worsened as the Spring Festival approached. I woke up several times at night due to the pain and really couldn’t fall asleep! Through a friend’s recommendation, I got in touch with Dr. Li.
Treatment Process:
After Dr. Li reviewed my MRI images online, he immediately diagnosed that bone spurs had caused acromion impingement, leading to a rotator cuff tendon tear, and that minimally invasive surgery could be performed! With Dr. Li’s patient explanations and guidance, I had an in – person consultation with him on January 16, 2023. After that, I completed the hospital admission procedures, and the surgery was scheduled the next day.
Recovery Status:
On the third day, I could start climbing the wall with my post – operative arm under the doctor’s guidance! Today is the fifth day after my surgery, and I can clearly feel that my recovery is getting better and better. By sticking to wall – climbing exercises every day, my progress is very remarkable! The range of motion of my arm is vastly different from before the surgery! My life is full of hope again! Looking back on my medical journey, I feel extremely fortunate to have met Dr. Li! I am grateful to Teacher Gu who recommended Dr. Li to me, and to Dr. Li and his team. Their exquisite skills, humble demeanor, and patient, meticulous guidance gave me the courage to face the surgery, motivated me to actively exercise after the surgery, and helped me regain my health!

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